Platelet Rich Fibrin

Platelet rich fibrin (PRF) is a by-product of blood (plasma) that is rich in platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 10-50 cc of blood, which is drawn from the patient while they are having outpatient surgery.

Why All The Excitement About PRF?

PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cell types to the wound in order to initiate the healing process. Platelets are one of those cell types. Platelets perform many functions, including formation of a blood clot and release of growth factors (GF) into the wound. These growth factors; platelet derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more your body’s cells are stimulated to produce new tissue. Thus, PRF can help the body to heal faster and more efficiently.

PRF Has Many Clinical Applications

PRF can be used to aid in tissue healing. This includes sinus lift procedures, ridge augmentation procedures, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

PRF Also Has Many Advantages

Safety: PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.

Convenience: PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.

Faster healing: The supersaturation of the wound with PRF, and thus growth factors, helps your body to heal wounds with potentially faster healing.

Cost effectiveness: Since PRF harvesting is done with only 10-50 cc of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in hospital or at a blood bank.

Ease of use: PRF is easy to handle and can help improve the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About PRF

Is PRF safe? Yes. During the outpatient surgical procedure a small amount of your own blood is drawn out via the IV. This blood is then placed in the PRF centrifuge machine and spun down. In less than 15 minutes, the PRF is formed and ready to use.

Should PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for PRF.

Will my insurance cover the costs? Unfortunately not. The cost of the PRF application is usually paid by the patient.

Can PRF be used alone to stimulate bone formation? No. PRF should generally be used with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product.

Are there any contraindications to PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon to determine if PRF is right for you.